In this guide, the Federal Highway Administration (FHWA) describes a scalable framework which transportation agencies can use to perform a systemwide safety risk assessment of their roadway system. Such an approach is analogous to the traditional crash-based network screening methodology, with one clear distinction: whereas agencies traditionally assess roadways using crash-based measures (e.g., observed or expected crash frequency), this approach allows agencies to assess roadways using a risk-based approach (i.e., potential risk of a severe crash).